Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion.
New Hope for Depression
About 30% of all people with depression don’t respond adequately to the available treatments. That’s a dismal failure rate for a class of drugs designed to improve a person’s basic ability to function...
Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis
This study suggests that ketamine is effective in treatment-resistant bipolar depression and may reduce suicidal ideation and anhedonia.
The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review
At least 10-20% of the patients suffering from depression meet criteria for treatment-resistant depression (TRD)...
Ketamine therapy treatment of major depressive episodes: a systematic review
Our meta-analysis suggests that single administrations ketamine therapy are efficacious in the rapid treatment of unipolar and bipolar depression.
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment.
Ketamine Infusion Therapy for Psychiatric Disorders and Chronic Pain Management
The clinical use of ketamine infusion therapy for psychiatric disorders and chronic pain management continues to evolve.
Ketamine for chronic pain: risks and benefits
The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those that have a neuropathic component. Low dose ketamine produces strong analgesia in neuropathic pain states ...
Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization
Allodynia is a well-known component of neuropathic pain resulting from injury to the nervous system.
Prolonged Analgesic Effect of Ketamine, anN-Methyl-d-Aspartate Receptor Inhibitor, in Patients with Chronic Pain
We examined the role of N-methyl-D-aspartate (NMDA) receptors in chronic (pathological) pain in humans by using the NMDA receptor antagonist ketamine as a probe.