Kane said that using ketamine to successfully treat the disorder's most stubborn cases might just be "the biggest breakthrough in mental health in the last 50 years."
There’s more proof that ketamine works for depression
Now, in a new study published in the journal Nature, scientists have more proof of how ketamine works in the brain to trigger fast-acting antidepressant effects.
Serial infusions of low-dose ketamine for major depression
Single infusions of ketamine have been used successfully to achieve improvement in depressed patients.
Ketamine as a Novel Antidepressant: From Synapse to Behavior
This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry and behavioral levels and describes an integrated model of the action of ketamine in…
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD).
Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
Ketamine is reported to have rapid antidepressant effects, however there is limited understanding of the time-course of ketamine effects beyond a single infusion.
Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
In the current report, we examined the pattern and durability of antidepressant effects of repeated ketamine infusions in a larger sample, inclusive of the original.
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Depressed patients report the alleviation of major depressive disorder symptoms within two hours of a single, low-dose intravenous infusion of ketamine, with effects lasting up to two weeks.
A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects—for instance, within a few hours or days—would have an enormous impact on patient care and…
Effects of Ketamine on Major Depressive Disorder in a Patient With Posttraumatic Stress Disorder
It is proposed that ketamine has potential for treatment of major depression associated with posttraumatic stress disorder (PTSD) in combat veterans... Of particular note was his experience of normalized and restorative sleep, as well as…